For Games Design and animation, colleges and industry
Cinema4D is the motion graphics choice with one of the best 3D interfaces around. There is a basic version hiding inside Adobe After Effects CC.
Blender 3d is a powerful and interesting free open source alternative for Macs and PCs which stands out for recent developments in mixing 2D and 3D animation.
Autodesk Mudbox, free to students as part of the Autodesk licence.
Pixologic zBrush. Given the professional price of zBrush is $895 you may want to look at the more basic zBrush Core at $179.99.
3D Coat has a 30 day free trial, and an amateur licence from $99.
Blender 3d has a sculpt mode.
Autodesk Maya has a sculpt mode.